Robert H. Vonderheide

Deep learning representations of human Immune Health for precision immunology

The paper develops MAESTRO, a self-supervised deep learning framework to transform immune profiles into embeddings capturing immune health, enabling clinical prediction and precision immunotherapy.

An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences

The paper presents a cost-effective, non-commercial protocol for normalizing TCRβ CDR3 sequencing data to correct amplification bias in bulk TCR repertoire profiling.