Joy Lincoln

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This study uses single-cell transcriptomics to identify cell heterogeneity in murine aortic valves at birth, revealing novel subpopulations and their developmental trajectories.

This study demonstrates an efficient chemical method to generate iPSCs from frozen umbilical cord tissue, highlighting its safety and potential for regenerative medicine.

The paper shows that DICER1 activity is essential for mitral valve development but not tricuspid valve development, revealing miRNA-mediated gene regulation as a differential mechanism.