R. Craig

Annotating the X-ray diffraction pattern of vertebrate striated muscle

The paper uses an atomic model of the human cardiac thick filament to compute contributions of different components to X-ray diffraction patterns, confirming some interpretations and contradicting others.

Origin and evolutionary trajectories of brown algal sex chromosomes

The paper analyzes brown algal genomes to trace the origin and evolution of U/V sex chromosomes, revealing gene gain-driven evolution and the demise of these systems through hermaphroditism and gene hierarchy shifts.

Cryo-EM structure of the human cardiac myosin filament

This paper solves the cryo-EM structure of the human cardiac myosin filament, revealing the arrangement of myosin, cMyBP-C, and titin and their functional interactions.

Rates and spectra of de novo structural mutation in Chlamydomonas reinhardtii

This study estimates the rate and spectrum of structural mutations in two strains of Chlamydomonas reinhardtii using long-read sequencing, revealing strain-specific variation and associations with transposable elements.

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle

The paper uses X-ray diffraction and electron microscopy to show that rat soleus muscle has a simple thick filament lattice, while extensor digitorum longus has a super lattice, correlating with slow and fast fiber types respectively.

The central role of the tail in switching off myosin II in cells

The paper reveals the structural mechanism by which the tail of myosin II inhibits its activity by interacting with the heads to block ATP hydrolysis, actin binding, and filament formation.