Zachary B. Gaber

This paper presents a cell-free method to rapidly produce and determine cryo-EM structures of GPCR-nanodisc complexes, achieving structural-grade results in four days.

The paper shows that hippocampal stem cells in mice undergo progressive behavioral changes that reduce depletion and ensure lifelong neurogenesis.

The paper shows Bcl6 promotes neurogenic conversion by repressing extrinsic self-renewal pathways like Wnt through transcriptional silencing.

The paper uses single cell transcriptomics to study Olig2 and Hes regulatory dynamics during motor neuron differentiation, revealing Olig2's role in repressing Hes5 and coordinating differentiation timing.