Philipp Voigt

Nucleosomal Asymmetry Shapes Histone Mark Binding and Promotes Poising at Bivalent Domains

The paper shows that asymmetric bivalent nucleosomes at developmental gene promoters promote a poised state by recruiting repressive H3K27me3 binders and specific chromatin proteins like KAT6B, which is critical for ESC differentiation.

H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability

This study shows that H3.1K27M disrupts chromatin maturation, leading to TSK/TONSL activation and genomic instability in Arabidopsis.

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

The paper shows that DDM1 remodels histone H3 variants to facilitate epigenetic inheritance of DNA methylation by interacting with specific histone modifications and variants.

Histone marks are drivers of the splicing changes necessary for an epithelial-to-mesenchymal transition

The paper shows that histone marks H3K27ac and H3K27me3 drive splicing changes during epithelial-to-mesenchymal transition by modulating splicing factor recruitment.

The TAZ2 domain of CBP/p300 directs acetylation towards H3K27 within chromatin

This study identifies the TAZ2 domain of CBP/p300 as essential for directing acetylation towards H3K27 in chromatin, enhancing specificity and gene expression regulation.

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.