Hongmei Wang

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

This paper describes a transgene-free human embryo model that recapitulates peri-gastrulation development, including trilaminar embryonic disc and yolk sac-like structures.

CellPolaris uses transfer learning to generate cell-type-specific gene regulatory networks from transcriptomic data, achieving state-of-the-art results in predicting regulatory factors and simulating cell fate transitions.

The paper constructs a longitudinal single-cell atlas of cynomolgus monkey ovaries across 22 years, identifies a novel oocyte type, and develops a transcriptomic ovarian clock applicable to humans.

The paper shows that sperm cooperation in mice forms clusters at the utero-tubal junction, facilitating oviduct entry and fertilization, with defects in this process linked to infertility.