Ziad Al Tanoury

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

This study compares 3D skeletal muscle spheroids (iSMS) with 2D cultures for modeling Duchenne Muscular Dystrophy, finding improved PAX7 expression and altered Notch signaling in iSMS.

Reconstructing human Brown Fat developmental trajectory in vitro

This study uses single-cell RNA sequencing to identify brown fat precursors and demonstrates their in vitro differentiation into functional brown adipocytes.

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

This study shows that mechanical tension drives multi-scale self-organisation in human iPSC-derived muscle fibers by coordinating sarcomere assembly and myofiber bundling.

In vitro characterization of the human segmentation clock

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.

Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro

This study develops an in vitro protocol to recapitulate early paraxial mesoderm development in mouse ES cells, showing efficient differentiation into muscle precursor cells and functional muscle fibers.