Author

Ryan T. Mikami

Washington University in St. LouisORCID 0009-0008-2081-4147Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Ashutosh KumariD· 2 shared John D. TranteriD· 2 shared Litao XieiD· 2 shared Nihil AbrahamiD· 2 shared Rajan SahiD· 2 shared Yonghui ZhaoiD· 2 shared Abhinav DiwaniD· 1 shared Abigail AjaneliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCell Biology

Ashutosh KumarORCID

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2 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedSep 26, 2025

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

Ashutosh Kumar, Yonghui Zhao, Litao Xie…·Rajan Sah

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

9 citationstop 3%

mousegenetic perturbation / CRISPR

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Cell BiologyBloodPeer-reviewedJun 20, 2025

LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis

John D. Tranter, Ryan T. Mikami, Ashutosh Kumar…·Rajan Sah

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

12 citationstop 2%

mouseproteomics

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