ImmunologyScience ImmunologyPeer-reviewed
Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade
Andrew J. Snyder, Sarah M. Garrison, Mitchell G. Kluesner…·Shivani Srivastava
This study shows that overexpressing c-Jun in CAR-T cells enhances their ability to maintain PD-1+Tcf1+ stem-like cells in tumors and improves response to PD-L1 blockade.
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