Author

Mohammed-Alkhatim A. Ali

University of PennsylvaniaORCID 0000-0002-1546-7725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. John WherryiD· 2 shared Shin Foong NgiowiD· 2 shared Víctor AlcaldeiD· 2 shared Allison R. GreenplateiD· 1 shared Amie AlbertusiD· 1 shared Amy E. BaxteriD· 1 shared Angela R. CorriganiD· 1 shared David B. WeineriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

E. John WherryORCID

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2 papers

Recent·Most cited

ImmunologyScience ImmunologyPeer-reviewedMay 29, 2026

In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP

Angela R. Corrigan, Shin Foong Ngiow, Maura Statzu…·Michael R. Betts

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

1 citation

mouserat

𝕏 PostBluesky

ImmunologybioRxivPreprintMay 18, 2026

PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance

Shin Foong Ngiow, Ryan P. O’Connell, Sasikanth Manne…·E. John Wherry

The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky