Jules Nde

The paper uses an integrative approach to model the structure of an IDR-driven HDAC2 complex, revealing interactions not captured by AlphaFold alone.

The paper builds structural models of HDAC1/2-containing chromatin remodeling complexes using XL-MS and integrative modeling, revealing how the CTD IDR of HDAC1 folds into alpha helices.

The paper presents a computational model of the S. cerevisiae INO80 chromatin remodeling complex using integrative methods, revealing the structure and dynamics of key modules and introducing the INTEGRATOR workflow tool.

The paper investigates how dual-role regulators interact with the Sin3 complex using structural and functional analyses, revealing mechanisms for transcriptional crosstalk.

The paper identifies how the BRCA1-Y1853ter mutation alters protein interactions and cellular processes, suggesting gain-of-function effects in cancer.

The paper introduces iSeq, a tool for analyzing DSB-sequencing data, enabling identification and annotation of DSB-enriched regions across various resolutions.

qDSB-Seq quantifies absolute DNA double-strand break frequencies and their genomic coordinates across samples and organisms.