Author

Cassandra G. Kempf

Stowers Institute for Medical ResearchORCID 0000-0002-4891-0113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Laurence A. FlorensiD· 4 shared Michael P. WashburniD· 4 shared Janet L. Thornton· 3 shared Rosalyn C. ZimmermanniD· 3 shared Jerry L. WorkmaniD· 2 shared Joseph CesareiD· 2 shared Jules NdeiD· 2 shared Sayem MiahiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersSystems Biology

Laurence A. FlorensORCID

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4 papers

Recent·Most cited

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex

Jules Nde, Cassandra G. Kempf, Rosalyn C. Zimmermann, Joseph Cesare, Ying Zhang, Jerry L. Workman, Laurence A. Florens, Michael P. Washburn

The paper uses an integrative approach to model the structure of an IDR-driven HDAC2 complex, revealing interactions not captured by AlphaFold alone.

Journal of Proteome Research · Sep 9, 2026Peer-reviewedBiochemistry

Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome

Jules Nde, Kartik Majila, Rosalyn C. Zimmermann, Cassandra G. Kempf, Ying Zhang, Joseph Cesare, Janet L. Thornton, Jerry L. Workman, Laurence A. Florens, Shruthi Viswanath, Michael P. Washburn

The paper builds structural models of HDAC1/2-containing chromatin remodeling complexes using XL-MS and integrative modeling, revealing how the CTD IDR of HDAC1 folds into alpha helices.

Molecular & Cellular Proteomics · Sep 2, 2026Peer-reviewedSystems Biology

Beyond the Sin3/HDAC Complex: FAM60A emerges as a regulator of RNA Splicing

M. Nazmul Huda, Rosalyn C. Zimmermann, Preeti Nagar, Jahangir Alam, Md. Rafikul Islam, Gerald Dayebgadoh, Mojnu Miah, Cassandra G. Kempf, Janet L. Thornton, Ying Zhang, Zhihui Wen, Gaye Hatem, Allen J. Gies, Stephanie D. Byrum, Mohammad Alinoor Rahman, , Sayem Miah

This study identifies FAM60A as a regulator of RNA splicing, showing it interacts with HDAC1 and spliceosome components, expanding its known role beyond the Sin3/HDAC complex.

bioRxiv · Jan 16, 2024 · PreprintMolecular Biology

Differential complex formation via paralogs in the human Sin3 protein interaction network.

Mark K. Adams, Charles A.S. Banks, Janet L. Thornton, Cassandra G. Kempf, Ying Zhang, Sayem Miah, Yan Hao, Mihaela E. Sardiu, Maxime Killer, Gaye L. Hattem, Alexis Murray, Maria L. Katt, Laurence A. Florens, Michael P. Washburn

The paper investigates how paralog switching affects Sin3 complex interaction networks in humans, revealing shared and distinct interactions between SIN3A and SIN3B.

Molecular & Cellular Proteomics · May 28, 2020Peer-reviewedSystems Biology