Mihaela E. Sardiu

INTEGRATOR: Structural Elucidation of the INO80 Chromatin Remodeler via Experimentally Guided Molecular Simulations

The paper presents a computational model of the S. cerevisiae INO80 chromatin remodeling complex using integrative methods, revealing the structure and dynamics of key modules and introducing the INTEGRATOR workflow tool.

Differential Remodeling of the BRCA1 Interactome by a Unique Minimal Clinical Truncation Mutation

The paper identifies how the BRCA1-Y1853ter mutation alters protein interactions and cellular processes, suggesting gain-of-function effects in cancer.

PerSEveML: A Web-Based Tool to Identify Persistent Biomarker Structure for Rare Events Using Integrative Machine Learning Approach

PerSEveML identifies persistent biomarker structures for rare events using an integrative machine learning approach and provides visualization tools for hypothesis generation.

Transcriptomic Gene Network Profiling and Weak Signal Detection for Prediction of Ovarian Cancer Occurrence, Survival, and Severity by Integrating Bulk and Single-cell RNAseq Data

The paper integrates bulk and single-cell RNAseq data to identify predictive gene networks and weak genes for ovarian cancer occurrence, survival, and clinical stage using netLDA, improving prediction performance.

Dynamic regulation and requirement for ribosomal RNA transcription duringmammalian development

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.

Identification of Stem Cells from Large Cell Populations with Topological Scoring

The paper applies the TopS method to flow cytometry data to identify rare cell populations in a human hematopoietic stem cell dataset.

Differential complex formation via paralogs in the human Sin3 protein interaction network.

The paper investigates how paralog switching affects Sin3 complex interaction networks in humans, revealing shared and distinct interactions between SIN3A and SIN3B.

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome

The paper maps the WDR76 interactome using AP-MS and identifies key interactions with the CCT complex and other proteins, validating interactions with GAN and SIRT1.

Topological Scoring of Protein Interaction Networks

The paper introduces TopS, a method to score protein interactions in proteomic datasets, revealing direct interactions and modules in human and yeast networks.

A new coactivator complex required for retinoic acid-dependent regulation of embryonic symmetry

The paper identifies a novel protein complex, WHHERE, that regulates retinoic acid signaling and embryonic symmetry by controlling histone modifications and RNA Polymerase II recruitment.