Ivan M. Munoz

NEK1 autophosphorylation is disrupted by amyotrophic lateral sclerosis-associated missense variants: activity biomarkers and structural insights

Kinase-dead controls, XIC quantification and phosphospecific antibodies establish pSer14, pThr156 and pSer418 as NEK1 autophosphorylation sites; a pThr156 assay shows ALS missense variants differ, with R261C reducing it most.

A PLK1-Directed Mitotic Genome Maintenance Network Promotes DNA Synthesis in Mitosis

This study identifies PLK1-associated DNA repair factors and shows PLK1's role in mitotic DNA synthesis through specific interactions with SLX4 and RAD52.

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

This study identifies SINHCAF/FAM60A as a component of the SIN3A-HDAC complex that regulates the hypoxia response and shows its inverse correlation with HIF2 mRNA levels, predicting cancer patient survival.