Samrat Basak

Self-blinking dye restores efficient use of nanobodies in single-molecule localization microscopy.

This paper demonstrates that self-blinking dye JF635b improves nanobody performance in single-molecule localization microscopy, enabling reliable imaging across multiple modalities with high precision.

A generalizable interface-seeded framework for de novo design of functional oligomers

This paper introduces an AI-based framework for designing responsive protein oligomers that assemble in response to chemical or phosphorylation triggers, validated through experimental testing.

Nanobodies equipped with HaloTag variants enable rapid and straightforward one-step immunofluorescence lifetime multiplexing

The paper introduces nanobody-HaloTag constructs for multiplexed immunofluorescence imaging, enabling up to eight targets with lifetime and spectral encoding in a single step.

High-Performance, Computer-Controlled Bipedal DNA Motor

This paper describes a high-fidelity, computer-controlled DNA motor that moves bidirectionally with high efficiency and precision, outperforming previous designs.

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

This study uses super-resolution imaging to reveal the dynamic nanoscale architecture of CaV1.3 channel clusters in cardiac myocytes, showing mobile channels within nanodomains rather than dense packing.

A versatile microfluidics platform for enhanced multi-target super-resolution microscopy

This paper introduces a microfluidics platform for multiplexed super-resolution microscopy, demonstrating its use in imaging cancer and cardiac cells with high reproducibility.

A High-Performance and Recoverable DNA Origami Rotary Motor

This paper develops a DNA origami rotary motor that can perform multiple revolutions and recover from operational errors using microfluidic control and high-resolution imaging.

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

This paper introduces MIET-PAINT, a method combining DNA-PAINT and Metal-Induced Energy Transfer to achieve nanometer-scale 3D imaging with high multiplexing capability.