Joseph L. Bedont

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

This study identifies polyamine elevation and nitrogen stress as toxic consequences of chronic sleep loss in Drosophila, linking them to metabolic dysfunction and reduced survival.

This study identifies a conserved clock-regulated neural network in mice and Drosophila that controls arousal and sleep, showing that mWake+ cells are critical for circadian-dependent neural excitability.