Jianing Yang

Mitochondrial coenzyme Q redox balance restrains dopaminergic neuron activity to promote early-life sleep in Drosophila

This study identifies coenzyme Q redox balance as a regulator of dopaminergic neuron activity and juvenile sleep in Drosophila by linking mitochondrial complex I function to sleep fragmentation and depth.

Glia mediate brain-wide activity and sleep behavior during sickness through an adrenergic-glutamatergic axis

This study identifies glia as key coordinators of sickness-induced sleep behavior through an adrenergic-glutamatergic axis in Drosophila.

Tanycyte Bmal1 sex-specifically regulates weight gain and hypothalamic neurogenesis in female mice

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.