Wei Zhang

LineageFlow: Growth-Corrected State Dynamics for Probabilistic Cell-Fate Prediction

LineageFlow predicts clonal fate and transcriptional profiles by integrating growth dynamics and state transitions in single-cell lineage data.

Drosophila Arc1 is required for metabolic resilience and developmental timing during dietary challenges

This study shows that Arc1 in Drosophila regulates metabolic resilience and developmental timing in response to dietary changes by linking insulin signaling to metabolic and developmental gene expression.

Deep contrastive learning enables genome-wide virtual screening

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

A heart releasing neuropeptide that synchronizes brain-heart regulation during courtship behavior

The paper identifies a brain-heart axis that regulates mating states through neuropeptides in flies and mice, and develops a computational framework to decode these states from cardiac physiology.

Pharyngeal Mechanosensory Neurons Control Food Swallow in Drosophila melanogaster

This study identifies pharyngeal mechanosensory neurons in Drosophila that regulate food swallowing by coordinating cibarium filling and emptying through mechanotransduction channels.

Selfee: Self-supervised Features Extraction of animal behaviors

Selfee extracts comprehensive and discriminative features from raw animal behavior videos using self-supervised learning, enabling anomaly detection and temporal analysis.

Molecular Mechanisms for Frequency Specificity in a Drosophila Hearing Organ

The paper identifies molecular mechanisms for frequency specificity in Drosophila hearing by showing Brv1 and Pzl in lch5 neurons mediate specific frequency ranges, with Piezo2 function conserved across species.