Author

Myron I. Cybulsky

University Health NetworkORCID 0000-0002-1696-2867Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Kenneth K. Y. TingiD· 2 shared Hisham M. IbrahimiD· 1 shared Jonathan V. RocheleauiD· 1 shared Nitya GulatiiD· 1 shared Yufeng WangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

Kenneth K. Y. TingORCID

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2 papers

Recent·Most cited

Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response

Kenneth K. Y. Ting, Hisham M. Ibrahim, Nitya Gulati, Yufeng Wang, Jonathan V. Rocheleau, Myron I. Cybulsky

This study shows that free cholesterol accumulation in macrophages activates a PARP1 response to DNA damage, which suppresses lipopolysaccharide-induced inflammation through a non-enzymatic mechanism.

PLoS ONE · Mar 5, 2025Peer-reviewedImmunology

Cholesterol accumulation-induced impairment of AKT signaling in LPS-stimulated macrophages play a dispensable role in suppressing HIF-1α-dependent glycolysis

Kenneth K. Y. Ting, Myron I. Cybulsky

This study shows cholesterol accumulation in macrophages impairs AKT signaling and HIF-1α-dependent glycolysis, but these effects are not synergistic in suppressing inflammation.

bioRxiv · Sep 1, 2024 · PreprintImmunology