Author

Hisham M. Ibrahim

University Health NetworkORCID 0000-0003-3020-0487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Jonathan V. RocheleauiD· 1 shared Kenneth K. Y. TingiD· 1 shared Myron I. CybulskyiD· 1 shared Nitya GulatiiD· 1 shared Yufeng WangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Jonathan V. RocheleauORCID

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1 paper

Recent·Most cited

ImmunologyPLoS ONEPeer-reviewedMar 5, 2025

Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response

Kenneth K. Y. Ting, Hisham M. Ibrahim, Nitya Gulati…·Myron I. Cybulsky

This study shows that free cholesterol accumulation in macrophages activates a PARP1 response to DNA damage, which suppresses lipopolysaccharide-induced inflammation through a non-enzymatic mechanism.

8 citations

mousebulk RNA-seq

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