Kenneth K. Y. Ting

Apollo-IRE1 is a genetically encoded sensor that detects ER stress by measuring IRE1 oligomerization and fluorescence anisotropy changes, enabling multiplexed imaging in living cells.

This study shows that free cholesterol accumulation in macrophages activates a PARP1 response to DNA damage, which suppresses lipopolysaccharide-induced inflammation through a non-enzymatic mechanism.

This study shows cholesterol accumulation in macrophages impairs AKT signaling and HIF-1α-dependent glycolysis, but these effects are not synergistic in suppressing inflammation.