BiophysicsbioRxivPreprint
A shear lag model of the podocyte foot process network predicts a mechanical feedback loop driving progressive effacement
Mingxuan Bi, Hanxun Jin, Pongpratch Puapatanakul…·Guy M. Genin
DOI 10.64898/2026.07.15.738799
Author
Chengqing Qu
Washington University in St. LouisORCID 0000-0002-1719-8354Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2026-2026 · peak 3/yrCo-Author Collaboration Network
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- BiophysicsbioRxivPreprint
Synaptopodin enables directional mechanoadaptation of integrin-based adhesions
Chengqing Qu, Yuxuan Huang, Shumeng Jiang…·Hani Y. Suleiman
The paper shows synaptopodin enables cells to adapt their adhesion structures to resist perpendicular forces by reorganizing the actin cytoskeleton and integrin-based adhesions.
DOI 10.64898/2026.01.25.701551 - Cell BiologybioRxivPreprint
Orthogonal Force Balance Between Contractility and Shear Stress Governs Podocyte Dynamics
Shumeng Jiang, Pongpratch Puapatanakul, Chengqing Qu…·Hani Y. Suleiman
The paper identifies a mechanical homeostasis mechanism in podocytes where balance between fluid shear stress and cellular contractility prevents injury, showing that reducing blood pressure can worsen outcomes when contractility is impaired.