Christina Marcelo Leyson

Within-host antigenic selection of influenza A virus dominates over stochasticity but is limited by fitness tradeoffs and timing of the immune response

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction

The paper develops chicken lung organoids to model avian influenza virus-host interactions and finds they contain diverse cell types and express relevant viral infection genes.

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

Viral lineage and mode of exposure modulate within host spatial dynamics of influenza A viruses

This study shows that influenza A virus lineage and exposure route affect its spatial distribution and genetic diversity within the respiratory tract of guinea pigs.

A systematic review of laboratory investigations into the pathogenesis of avian influenza viruses in wild avifauna of North America

This study reviews laboratory studies on avian influenza virus infection in wild North American birds to assess susceptibility and transmission parameters.