Ashley Tucewicz

Cell-type specific developmental defects in PTEN-mutant cortical organoids converge on abnormal circuit activity

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortex

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.