Mahendra S. Sonawane

The paper shows ROCK maintains tight junction barrier function in zebrafish epidermis under hypoxia by mediating cell shape changes and suppressing delamination.

This study shows mTOR regulates epithelial apical projections through S6K1-RhoA and aPKC-Lgl2 pathways in zebrafish.

This study identifies mTOR-dependent macropinocytosis in zebrafish periderm as a nutrient acquisition mechanism during epidermal development.

This study shows that chronic sucrose water consumption in mice rewires tissue-specific molecular mechanisms, leading to systemic metabolic dysfunction including impaired glucose homeostasis and mitochondrial dysfunction.

The paper introduces the STIPS algorithm to track merging and splitting events in dynamic biopolymer networks, revealing distinct rhythmic dynamics in actin microridges.

The paper develops a deep learning framework to segment actin microridges in zebrafish epidermal cells, enabling quantitative analysis of their mechanical and dynamic properties.

The paper investigates the role of Satb2 in regulating zygotic genome activation and developmental transitions during vertebrate embryogenesis, showing distinct maternal and zygotic functions.