Anshit Singh

This study shows that caloric restriction in mice alters RNA processing and lipid composition across adulthood, linking these changes to metabolic reprogramming and lifespan extension.

The paper identifies a gut microbial metabolite of methotrexate that alleviates gut inflammation by promoting mitochondrial STAT3 signaling.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

This study identifies diurnal variation in mitochondrial function as a key determinant of time-of-day-dependent exercise capacity in skeletal muscle.

This study shows that chronic sucrose water consumption in mice rewires tissue-specific molecular mechanisms, leading to systemic metabolic dysfunction including impaired glucose homeostasis and mitochondrial dysfunction.