Author

Lee Phillimore

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Andrea CrisantiiD· 2 shared Austin BurtiD· 2 shared Federica BernardiniiD· 2 shared Matthew Gribble· 2 shared Tony NolaniD· 2 shared Andrew HammondiD· 1 shared Bhavin S. KhatriiD· 1 shared Christian BökeliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSynthetic Biology

Andrea CrisantiORCID

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3 papers

Recent·Most cited

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

Ignacio Tolosana, Katie Willis, Matthew Gribble, Lee Phillimore, Austin Burt, Tony Nolan, Andrea Crisanti, Federica Bernardini

The paper introduces a Y chromosome-linked genome editor (YLE) for population suppression in Anopheles gambiae, showing it is up to 8 times more efficient than other self-limiting strategies.

Nature Communications · Jan 2, 2025Peer-reviewedSynthetic Biology

Engineering Resilient Gene Drives Towards Sustainable Malaria Control: Predicting, Testing and Overcoming Target Site Resistance

Ioanna Morianou, Lee Phillimore, Bhavin S. Khatri, Louise Marston, Matthew Gribble, Austin Burt, Federica Bernardini, Andrew Hammond, Tony Nolan, Andrea Crisanti

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

bioRxiv · Oct 21, 2024 · PreprintSynthetic Biology

Cell cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis

Diego Sainz de la Maza, Silvana Hof‐Michel, Lee Phillimore, Christian Bökel, Marc Amoyel

The paper shows that E2f1/Dp activity regulates mitochondrial activity in Drosophila CySCs, linking cell cycle exit and differentiation.

Cell Reports · May 1, 2022Peer-reviewedDevelopmental Biology