The paper introduces SNI, a framework to identify atypical protein assemblies, and applies it to NLRs, finding an undecameric assembly in NRC7 orthologs.

bioRxiv · May 4, 2026 · PreprintBioinformatics

Engineering Resilient Gene Drives Towards Sustainable Malaria Control: Predicting, Testing and Overcoming Target Site Resistance

Ioanna Morianou, Lee Phillimore, Bhavin S. Khatri, Louise Marston, Matthew Gribble, Austin Burt, Federica Bernardini, Andrew Hammond, Tony Nolan, Andrea Crisanti

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

bioRxiv · Oct 21, 2024 · PreprintSynthetic Biology

Regulation of gene drive expression increases invasive potential and mitigates resistance

Andrew Hammond, Xenia Karlsson, Ioanna Morianou, Kyros Kyrou, Andrea K. Beaghton, Matthew Gribble, Nace Kranjc, Roberto Galizi, Austin Burt, Andrea Crisanti, Tony Nolan

This study improves gene drive efficacy by reducing resistance and fitness costs through regulatory sequence modifications, leading to better population suppression and delayed resistance.

bioRxiv · Apr 4, 2020 · PreprintGenetics