Author

Rohit Sharma

Broad InstituteORCID 0000-0002-1847-682XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Fangcong DongiD· 2 shared Vamsi Krishna MoothaiD· 2 shared Carolina Mendez· 1 shared Catherine LapriseiD· 1 shared Christine Des RosiersiD· 1 shared Darryl C. De VivoiD· 1 shared Diana Atlas· 1 shared Eric A. Schon· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Fangcong DongORCID

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2 papers

Recent·Most cited

A genetically encoded redox bottleneck constrains human developmental rate

Gabriel E. Valdebenito, Jack P. Madden, Carolina Mendez, Leslie M. Azurdia, Xintao Zhu, Siyu Chen, Diana Atlas, Katherine Introcaso, Hao Zhang, 亚辉王, Fangcong Dong, Rohit Sharma, Vamsi Krishna Mootha, Gary J. Patti, Margarete Díaz-Cuadros

This paper identifies a genetic bottleneck in the G3P shuttle that limits human developmental rate by constraining metabolic flux and the segmentation clock.

bioRxiv · Sep 13, 2026 · PreprintDevelopmental Biology

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

Owen S. Skinner, María Miranda, Fangcong Dong, Tessa Struhl, Melissa Anne Walker, Grigorij Schleifer, Matthew T. Henke, Jon Clardy, Michio Hirano, Darryl C. De Vivo, Eric A. Schon, Kris Engelstad, Stephanie Siegmund, Catherine Laprise, Christine Des Rosiers, , Rohit Sharma

This paper identifies 4,5-dihydroxyhexanoic acid as a biomarker for mitochondrial disease severity and links it to GABA metabolism.

bioRxiv · Feb 12, 2026 · PreprintBiochemistry