Eric A. Schon

Cholesterol availability drives the assembly of mitochondria-associated ER membranes

This study shows that cholesterol availability through HDLs and SR-B1 drives MAM formation, which regulates ER-mitochondria communication and cholesterol metabolism.

Chronic ER Stress Disrupts Mitochondrial-Associated ER Membrane Integrity in Corneal Endothelial Cells.

This study examines how chronic ER stress disrupts mitochondrial-associated ER membrane integrity in corneal endothelial cells, showing increased ER-mitochondrial distance and altered MAM protein expression.

4,5-dihydroxyhexanoic acid is a robust circulating and urine marker of mitochondrial disease and its severity

This paper identifies 4,5-dihydroxyhexanoic acid as a biomarker for mitochondrial disease severity and links it to GABA metabolism.

Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer disease.

This study identifies how C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer's disease by remodeling MAMs and altering PC composition.

Serum Lipidome as an Early Peripheral Indicator in Familial Alzheimers Disease

The paper identifies a serum lipidomic signature in asymptomatic Alzheimer's disease mutation carriers that differentiates them from non-carriers and correlates with dementia risk factors.

The contribution of mitochondria-associated ER membranes to cholesterol homeostasis

This study shows that SR-B1-mediated cholesterol uptake from HDL stimulates MAM formation, which suppresses de novo cholesterol biosynthesis.