Jingyue Jia

This study shows SARS-CoV-2 ORF3a disrupts lysosomal cholesterol export by interfering with VPS39-regulated NPC2 trafficking and BMP metabolism.

This study identifies processing bodies (PBs) as critical for lysosomal quality control and cell survival during recovery from lysosomal damage, distinguishing their role from the acute damage response.

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

This study identifies amino acids that regulate lysosome positioning and shows that combining lysosome-dispersing amino acids with mTOR-activating ones synergistically enhances mTOR activation, particularly in cancer cells.

This study shows ATG5 and membrane atg8ylation regulate retromer function in GLUT1 trafficking, independent of canonical autophagy.