SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism
Baley A. Goodson, Valeria F. Montenegro Vazquez, Aliza Doyle, Oralia M. Kolaczkowski, Rui Liu, Jingyue Jia, Morié Ishida, Chunyan Ye, Alison M. Kell, Steven B. Bradfute, Mónica Rosas‐Lemus, Hu Wang, Xianlin Han, Jing Pu
This study shows SARS-CoV-2 ORF3a disrupts lysosomal cholesterol export by interfering with VPS39-regulated NPC2 trafficking and BMP metabolism.
Cell Reports · Jun 1, 2026Peer-reviewedCell Biology