Eliseo F. Castillo

Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome

This study identifies colonic metabolic and microbial changes in a mouse model of metabolic syndrome, showing similarities to human data and suggesting the colon as a potential therapeutic target.

Dietary Microplastics Engage Gut Mechanosensory-Endocrine Signaling and Disrupt Bone Homeostasis

This study shows that dietary microplastics alter gut neuroendocrine signaling and disrupt bone health in mice, with effects dependent on sex and diet.

Metabolomic, Lipidomic, and Enterohormone Changes in the Progression from MASLD to MASH

This study examines metabolomic, lipidomic, and enterohormone changes during progression from MASLD to MASH in mice, identifying cholic acid elevation and altered enteroendocrine hormone levels.

Photoaged microplastics disrupt endothelial stretch-sensitive ion channels to impair calcium signaling and vascular integrity

This study shows photoaged microplastics impair endothelial calcium signaling and vascular integrity by disrupting Piezo1-Notch mechanotransduction.

In vivo exposure of mixed microplastic particles in mice and its impacts on the murine gut microbiome and metabolome

This study shows that microplastic exposure alters gut microbiome composition and serum metabolome in mice, with sex-specific and dose-dependent effects.