Michael Farid

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level

The paper develops a transcriptomic entropy metric to benchmark maturation of PSC-derived cardiomyocytes against endogenous tissue using scRNA-seq data.

Quantitative comparison of in vitro and in vivo embryogenesis at a single cell resolution

The paper compares in vitro and in vivo embryogenesis using scRNA-seq data and computational tools to evaluate stem cell differentiation protocols.

The highly evolvable nature of the antibiotic efflux protein TolC limits use of phages and bacterial toxins as antibacterial agents

The study shows that the TolC protein in E. coli is highly evolvable, making it a target for resistance against bacteriophages and bacterial toxins.