David M. Curran

This study identifies a loopless subdomain of TbpB that elicits broad cross-reactive antibodies against diverse H. influenzae strains.

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.

Navargator selects representative variants based on phylogenetic trees to improve cross-reactivity in vaccines, validated using immunization studies.

The paper models the metabolic interactions between a parasitic worm and its bacterial endosymbiont to identify potential drug targets.