Scott J. Hultgren

This study designs miniprotein inhibitors targeting bacterial adhesins to prevent and treat urinary tract infections.

This paper develops a computational method to design glycoproteins with controlled N-linked glycan composition by encoding glycan location and structure into amino acid sequences.

This study identifies the Efg1 regulon active in C. albicans during growth in human urine, validates its clinical relevance in catheter samples, and characterizes key downstream factors involved in fungal CAUTI.

This study identifies metabolic cross-talk between Enterococcus faecalis and Klebsiella pneumoniae that promotes their persistence in catheter-associated urinary tract infections.

The paper predicts the structure and function of all proteins in uropathogenic E. coli UTI89 using computational methods and identifies novel host-microbe and microbe-phage interaction pathways.

This study shows that the lac operon in uropathogenic E. coli enables host glycan utilization, enhancing intracellular growth and infection dissemination.

This study identifies two monoclonal antibodies against FimH adhesin that protect mice from E. coli UTI by sterically blocking FimH function, offering an antibiotic-sparing treatment strategy.

ChronoStrain tracks low-abundance microbial strains over time with uncertainty quantification, outperforming existing methods on real and synthetic data.

This study identifies distinct E. coli transcriptional profiles in the guts of recurrent UTI sufferers using a novel pangenome hybrid selection method.

This study develops and tests GmPcides, dihydrothiazolo ring-fused 2-pyridone compounds, showing efficacy against Streptococcus pyogenes SSTI and biofilm formation.

StrainGE identifies low-abundance microbial strains from metagenomic data with higher sensitivity and resolution than existing tools.