Hiroshi Hama

This paper introduces OxyBLI, a noninvasive optical method to monitor tissue oxygenation in real-time, showing how hypoxia and hyperoxia affect oxygen distribution in experimental animals.

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

The paper identifies plaque-associated endogenous IgG in AD mouse models that interferes with immunohistochemical detection of mouse monoclonal IgG antibodies and shows that subclass-specific secondary antibodies can mitigate this issue.