Atsushi Miyawaki

OxyBLI: A Genetics-Based Approach for In Vivo Real-Time Visualization of Tissue Oxygenation Dynamics

This paper introduces OxyBLI, a noninvasive optical method to monitor tissue oxygenation in real-time, showing how hypoxia and hyperoxia affect oxygen distribution in experimental animals.

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development.

FuChi is a new Fucci-based system in chickens that accurately tracks cell cycle phases in vivo, improving upon existing models by distinguishing all phases and enabling detailed developmental studies.

Epilepsy protein myoclonin1 interacts with inositol 1,4,5-trisphosphate (IP3) receptor and reduces Ca2+ store in endoplasmic reticulum

This study identifies myoclonin1's interaction with IP3 receptors and PRKCSH, showing it modulates ER-Ca2+ homeostasis, which may contribute to epilepsy in EFHC1 mutation carriers.

A bright synthetic near-infrared luciferin enhances the capabilities of deep-tissue bioluminescence imaging using firefly luciferases

This paper introduces a synthetic near-infrared luciferin, AkaSuke, that enhances deep-tissue bioluminescence imaging with firefly luciferases by improving detection sensitivity.

Direct Intercellular Vesicle Exchange between Adjacent Cells

The paper discovers a new form of cell-cell communication called DIVE, where vesicles are directly transferred between adjacent cells, potentially enabling nucleic acid exchange and phenotypic synchronization.

Plaque-associated endogenous IgG and its impact on immunohistochemical detection of mouse monoclonal IgG antibodies in mouse models of Alzheimer's disease

The paper identifies plaque-associated endogenous IgG in AD mouse models that interferes with immunohistochemical detection of mouse monoclonal IgG antibodies and shows that subclass-specific secondary antibodies can mitigate this issue.

Distributed sensory coding by cerebellar complex spikes in units of cortical segments

The paper investigates how sensory signals are represented in the cerebellum by analyzing complex spikes in mouse brain segments.

Novel System to Monitor In Vivo Neural Graft Activity After Spinal Cord Injury

This paper introduces a non-invasive in vivo imaging system to monitor neural graft activity after spinal cord injury and shows graft integration with host behavior.

Fast scanning high optical invariant two-photon microscopy for monitoring a large neural network activity with cellular resolution

The paper introduces FASHIO-2PM, a two-photon microscope that enables fast, aberration-free calcium imaging of large neural networks in awake mice at 7.5 Hz.

Genetic manipulation of the optical refractive index in living cells

This paper demonstrates the manipulation of the optical refractive index in mammalian cells using cephalopod reflectin protein nanoparticles and shows their application in microscopy techniques.

In vitro characterization of the human segmentation clock

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.