Sasirekha Ramani

The paper isolates and characterizes small intestinal Lactobacillaceae strains, showing their ability to modulate host immune and hormonal responses in preclinical models.

This study shows microbiota-derived indole metabolites inhibit rotavirus infection in human infants and animal models through the AhR pathway.

This study identifies host restriction factors limiting HuNoV passaging in HIEs and demonstrates that TAK-779 enhances viral replication and enables continuous passaging.

This study shows that BTP2 inhibits Tulane virus and human norovirus replication by targeting structural proteins, not through SOCE, and establishes a system for antiviral screening.

This study identifies conformational flexibility in GII proteases as a key factor affecting inhibitor potency, guiding the design of broad-spectrum norovirus protease inhibitors.

This paper shows that 2'-fucosyllactose inhibits replication of a dominant human norovirus strain in intestinal enteroids from adult and pediatric donors.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

This paper presents a probe-based capture enrichment method to obtain full-length genomes of RSV and HuNoV from clinical samples, achieving high completeness and improving variant tracking.

The paper investigates how gut microbiota, particularly C. perfringens, affects rotavirus vaccine efficacy in mice and human children.

This study identifies major sources of transcriptomic variation in human intestinal organoids, showing that culture methods like substrate and format have large effects compared to experimental manipulations.