Steven Boeynaems

Lipoproteins modulate the uptake and biological functionof cationic cell-penetrating peptides across the animal lineage.

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

Mapping RNA structure assembly and remodeling in biomolecular condensates

This study introduces RAID-MaP to measure RNA structure within biomolecular condensates, revealing insights into rRNA folding and structural dynamics in the nucleolus and 7SK RNA.

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure

The paper investigates how the ultrastructure of biomolecular condensates, using PopZ as a model, influences their function through molecular interactions and phase-dependent conformational changes.

The big tau splice isoform resists Alzheimer's-related pathological changes

This study identifies big tau, a splice isoform of tau, as more abundant in brain regions resistant to Alzheimer's pathology and shows its protective properties in human patients.

Small molecule v-ATPase inhibitor Etidronate lowers levels of ALS protein ataxin-2

The paper identifies Etidronate, an FDA-approved drug, as a method to lower ataxin-2 levels in neurons using a CRISPR screen and validates its efficacy in mice.

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.