Joseph Hyungwoo Lee

Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling

The paper identifies protective SH3RF3 variants that delay Alzheimer's onset by reducing microglial inflammation through JNK and NFkB pathway modulation in PSEN1G206A carriers.

Utility of Polygenic Risk Scores in Families with Exceptional Longevity

This study evaluates polygenic risk scores (PRS) for predicting Alzheimer's disease risk in a cohort of families with exceptional longevity and finds limited predictive power due to population-specific genetic differences.

A Novel Gene ARHGAP44 for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (FOS)

The paper identifies ARHGAP44 as a novel gene associated with longitudinal changes in HbA1c in non-diabetic individuals using linkage and sequence analysis from two studies.

Rare variants imputation in admixed populations: Comparison across reference panels and bioinformatics tools.

This study compares imputation accuracy for rare and ultra-rare variants in an admixed Caribbean Hispanic population using different reference panels and tools, finding that larger reference panels improve imputation quality.