Kaare Christensen

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

The paper examines the relationship between erythrocyte count and mortality in older adults, finding a critical threshold below which mortality risk sharply increases.

The paper identifies epistatic interactions between HK1 and GCK genes affecting HbA1c levels using Bayesian methods and confirms findings in independent studies.

The paper integrates GWAS meta-analysis with human brain cell mapping to identify genetic loci and cell types involved in tinnitus, implicating the amygdala and midbrain.

The paper identifies pleiotropic genetic factors shared between kidney function and sRAGE using GWAS and TWAS in the LLFS cohort.

The paper identifies ARHGAP44 as a novel gene associated with longitudinal changes in HbA1c in non-diabetic individuals using linkage and sequence analysis from two studies.

A GWAS identified 20 rare genetic variants associated with better processing speed in the Long Life Family Study, replicated in Danish twin cohorts.

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

The paper identifies gene-environment interactions associated with orofacial cleft risk, highlighting VGLL2 and PRL as key genes interacting with alcohol and smoking, respectively.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

The paper develops a framework to analyze subtype-specific and shared genetic effects in orofacial clefting and applies it to identify loci associated with different subtypes.

The paper identifies age-related DNA methylation patterns on the X-chromosome in males and females and finds sex differences in their association with mortality.

The paper identifies sex-specific risk alleles for nonsyndromic orofacial clefts through genome-wide interaction studies, finding a significant gene-by-sex effect at the 10q21 locus.

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.