Jonathan A. Griffiths

A Spatiotemporal Atlas of Mouse Gastrulation and Early Organogenesis to Explore Axial Patterning and Project In Vitro Models onto In Vivo Space

This study creates a spatiotemporal atlas of mouse gastrulation and early organogenesis using spatial transcriptomics and scRNA-seq, revealing gene expression dynamics and mesodermal fate decisions.

Time, Space and Single-Cell Resolved Molecular Trajectory of Cell Populations and the Laterality of the Body Plan at Gastrulation

The paper constructs a single-cell spatio-temporal atlas of molecular trajectories during gastrulation in mouse embryos, revealing asymmetric BMP signaling and its role in left-right body plan asymmetry.

Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis

This paper uses spatial transcriptomics to study mouse organogenesis, revealing spatial gene expression patterns and cell fate decisions not captured by single-cell RNA sequencing.

An integrated polygenic and clinical risk tool enhances coronary artery disease prediction

This paper develops an integrated risk tool combining polygenic risk scores with clinical risk factors to improve coronary artery disease prediction, showing better performance than existing tools.

Detection and removal of barcode swapping in single-cell RNA-seq data

The paper quantifies barcode swapping in single-cell RNA-seq data and develops an algorithm to remove swapped reads, reducing artifacts in droplet-based experiments.