Author

Leland C. Mayne

University of PennsylvaniaORCID 0000-0001-6969-0474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 1 shared Bede PortziD· 1 shared Ben E. BlackiD· 1 shared Bo Lim LeeiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Christopher R. BrueiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Ashleigh SmirnovORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland C. Mayne, Miriam Linsenmeier, Jack D. Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, , James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

Science · May 7, 2026Peer-reviewedBiochemistry✦ In-depth digest

Structural Insights into the Role of the Proline Rich Region in Tau Function

Karen Acosta, Christopher R. Brue, Polina Holubovska, Hee Jong Kim, Leland C. Mayne, Kenji Murakami, Elizabeth R. Rhoades

This study investigates how phosphomimic mutations in tau's proline-rich region affect tubulin dimer binding and microtubule polymerization.

Structure · Jan 17, 2025Peer-reviewedBiophysics