Author

Ji-Sun Lee

University of Massachusetts Chan Medical SchoolORCID 0000-0002-2028-2493Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Jennifer S. Morgan· 2 shared Leslie M. ShawiD· 2 shared Anastasia KhvorovaiD· 1 shared Arminja Nadine KettenbachiD· 1 shared Arthur M. MercurioiD· 1 shared Ashley SummersiD· 1 shared Christi A. Silva· 1 shared Christopher D Dahlke· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Jennifer S. Morgan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell BiologyCell Death and DiseasePeer-reviewedApr 8, 2026

Interaction of IRS2 with PLK1 protects cells from mitotic stress

Ji-Sun Lee, Quyen Thu Bui, Minjeong Jo…·Leslie M. Shaw

This study identifies IRS2's role in protecting cells from mitotic stress through its interaction with PLK1, distinct from its signaling function.

1 citation

humanproteomics

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Cancer BiologyMolecular TherapyPeer-reviewedJan 29, 2026

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

Claire E. Tocheny, Julianna E. Buchwald, Christopher D Dahlke…·Leslie M. Shaw

This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.

1 citation

mouseexperimental assay

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