Author

Leslie M. Shaw

University of Massachusetts Chan Medical SchoolORCID 0000-0002-1946-2980Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Jennifer S. Morgan· 2 shared Ji-Sun LeeiD· 2 shared Alexander SpektoriD· 1 shared Anastasia KhvorovaiD· 1 shared Arminja Nadine KettenbachiD· 1 shared Arthur M. MercurioiD· 1 shared Ashley SummersiD· 1 shared Christi A. Silva· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Jennifer S. Morgan

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Author profile →

3 papers

Recent·Most cited

Interaction of IRS2 with PLK1 protects cells from mitotic stress

Ji-Sun Lee, Quyen Thu Bui, Minjeong Jo, Jennifer S. Morgan, Isha Nasa, Arminja Nadine Kettenbach, Leslie M. Shaw

This study identifies IRS2's role in protecting cells from mitotic stress through its interaction with PLK1, distinct from its signaling function.

Cell Death and Disease · Apr 8, 2026Peer-reviewedCell Biology

Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth

Claire E. Tocheny, Julianna E. Buchwald, Christopher D Dahlke, Hassan H. Fakih, Jennifer S. Morgan, Ashley Summers, Christi A. Silva, Samuel O. Jackson, Ji-Sun Lee, Michael-Anthony Card, Dimas Echeverria, Cornelia Peterson, Arthur M. Mercurio, Anastasia Khvorova, Leslie M. Shaw

This study delivers IRS2-targeting siRNAs to mammary tumors via albumin-binding dendrimers, reducing tumor growth by inhibiting Irs2 expression and altering tumor microenvironment features.

Molecular Therapy · Jan 29, 2026Peer-reviewedCancer Biology

Synergistic targeting of MCL1 and caspases for enhanced anti-tumor immunity in breast cancer.

Jae Kyo Yi, Jisun Lee, Pilhan Kim, Leslie M. Shaw, Alexander Spektor

This study shows that combining MCL1 and caspase inhibition enhances anti-tumor immunity in breast cancer by activating the cGAS-STING pathway and remodeling the tumor microenvironment.

bioRxiv · Oct 10, 2025 · PreprintCancer Biology