Author

Catherine Bowes Rickman

Duke UniversityORCID 0000-0002-8555-9596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Alexander TyshkovskiyiD· 2 shared Bruce R. KsanderiD· 2 shared Han SheniD· 2 shared James C. Cameron· 2 shared Jonathan S. WeissmaniD· 2 shared Lindsey A. ChewiD· 2 shared Meredith S. Gregory-KsanderiD· 2 shared Qiannuo LouiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Alexander TyshkovskiyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice

Yuancheng Ryan Lu, Han Shen, Kathrin M Kajderowicz, 艾家和, Yi Hua Chen-Neumann, Yan Hu, Alexander Tyshkovskiy, Qiannuo Lou, Tianwei Dong, Louisa Grauvogel, Zhaoyi Chen, James C. Cameron, Ximeng Li, 新多朗白濱, Michael Bligh, , Jonathan S. Weissman

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

bioRxiv · Sep 30, 2026 · PreprintGenetics

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

Yuancheng Ryan Lu, James C. Cameron, Yan Hu, Han Shen, Shintaro Shirahama, Alexander Tyshkovskiy, Zhaoyi Chen, Jiahe Ai, Daniel Y. Zhu, Margarete M. Karg, Lindsey A. Chew, George W. Bell, Siddhartha G. Jena, Yue He, Philip A. Seifert, , Jonathan S. Weissman

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

bioRxiv · Aug 30, 2025 · PreprintGenetics

Truncated Complement Factor H Y402 Gene Therapy Cures C3 Glomerulonephritis

Lindsey A. Chew, Daniel Grigsby, C. Garren Hester, Joshua Amason, W. Kyle McPherson, Edward J. Flynn, Meike Visel, Christopher R. Starr, John G. Flannery, Tylor R. Lewis, Catherine Bowes Rickman

This study shows that AAV-delivered truncated CFH gene therapy can reverse C3G in mice and suggests its potential for treating AMD.

Molecular Therapy · Apr 24, 2025Peer-reviewedPathology