Author

Kip M. Connor

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-2048-9080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:fine-mapping· 1 Assay:GWAS summary statistics· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Gopalan GnanaguruiD· 2 shared Gracia M. Bonilla· 2 shared Ruslan I. SadreyeviD· 2 shared Yoko OkunukiiD· 2 shared Bruce R. KsanderiD· 1 shared Charandeep SinghiD· 1 shared Daniel Ben-IsvyiD· 1 shared Drenushe Krasniqi· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

Gopalan GnanaguruORCID

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Author profile →

4 papers

Recent·Most cited

Loss of CFHR5 function reduces the risk for age-related macular degeneration

Mary Pat Reeve, Stephanie J. Loomis, Eija Nissilä, Thomas W. Soare, Tobias Rausch, Zhili Zheng, Pietro Della Briotta Parolo, Daniel Ben-Isvy, Elias Aho, Emilia Cesetti, Yoko Okunuki, Helen McLaughlin, Johanna Mäkelä, FinnGen, Mitja Kurki, , Heiko Runz

The paper identifies CFHR5 variants that reduce AMD risk by lowering FHR-5 levels and altering complement pathway activity.

Nature Communications · Jul 1, 2025Peer-reviewedGenetic & Genomic Medicine

Microglial depletion decreases Müller cell maturation and inner retinal vascular density

Nathaniel Rowthorn-Apel, Naveen Vridhachalam, Kip M. Connor, Gracia M. Bonilla, Ruslan I. Sadreyev, Charandeep Singh, Gopalan Gnanaguru

This study shows that microglia depletion reduces Müller cell maturation and inner retinal vascular density in mice.

Cell Communication and Signaling · Feb 17, 2025Peer-reviewedCell Biology

Retinal microglia exacerbate uveitis by functioning as local antigen-presenting cells

Shintaro Shirahama, Yoko Okunuki, May Y Lee, Margarete M. Karg, Nasrin Refaian, Drenushe Krasniqi, Kip M. Connor, Meredith S. Gregory-Ksander, Bruce R. Ksander

This study shows retinal microglia are critical antigen-presenting cells in uveitis, essential for all phases of disease, while CD11c+ DCs are not required for all phases.

Journal of Autoimmunity · Mar 27, 2024Peer-reviewedImmunology

Complement facilitates developmental microglial pruning of astrocyte and vascular networks

Gopalan Gnanaguru, Steven J. Tabor, Gracia M. Bonilla, Ruslan I. Sadreyev, Kentaro Yuda, Jörg Köhl, Kip M. Connor

This study shows that microglial complement signaling regulates astrocyte pruning and vascular development in the retina.

bioRxiv · Jan 12, 2022 · PreprintDevelopmental Biology