Author

Shintaro Shirahama

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-1864-0458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Bruce R. KsanderiD· 3 shared Margarete M. Karg· 3 shared Meredith S. Gregory-KsanderiD· 3 shared Alexander TyshkovskiyiD· 1 shared Anna M. PuszynskaiD· 1 shared Bohan ZhangiD· 1 shared Catherine Bowes RickmaniD· 1 shared Daisy Y. ShuiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Bruce R. KsanderORCID

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3 papers

Recent·Most cited

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

Yuancheng Ryan Lu, James C. Cameron, Yan Hu, Han Shen, Shintaro Shirahama, Alexander Tyshkovskiy, Zhaoyi Chen, Jiahe Ai, Daniel Y. Zhu, Margarete M. Karg, Lindsey A. Chew, George W. Bell, Siddhartha G. Jena, Yue He, Philip A. Seifert, , Jonathan S. Weissman

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

bioRxiv · Aug 30, 2025 · PreprintGenetics

A limbal stem cell deficiency murine model with residual limbal stem cells

Hideaki Someya, Shintaro Shirahama, Margarete M. Karg, Meredith S. Gregory-Ksander, Reza Dana, Bruce R. Ksander

This study creates a murine model of complete limbal stem cell deficiency with residual stem cells to investigate their function.

bioRxiv · Oct 17, 2024 · PreprintCell Biology

Retinal microglia exacerbate uveitis by functioning as local antigen-presenting cells

Shintaro Shirahama, Yoko Okunuki, May Y Lee, Margarete M. Karg, Nasrin Refaian, Drenushe Krasniqi, Kip M. Connor, Meredith S. Gregory-Ksander, Bruce R. Ksander

This study shows retinal microglia are critical antigen-presenting cells in uveitis, essential for all phases of disease, while CD11c+ DCs are not required for all phases.

Journal of Autoimmunity · Mar 27, 2024Peer-reviewedImmunology