Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision
Yuancheng Ryan Lu, James C. Cameron, Yan Hu, Han Shen, Shintaro Shirahama, Alexander Tyshkovskiy, Zhaoyi Chen, Jiahe Ai, Daniel Y. Zhu, Margarete M. Karg, Lindsey A. Chew, George W. Bell, Siddhartha G. Jena, Yue He, Philip A. Seifert, , Jonathan S. Weissman
OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.
bioRxiv · Aug 30, 2025 · PreprintGenetics